Angel horn donation: Research price 2007 - Break-through for active substance search

Peter and Traudl angel horn donation for the promotion of the biotechnology and genetic engineering - Logo (openPR) - diaphragm protein in natural folding synthesizes for the first time

• Peter and Traudl angel horn donation promote biotechnology and genetic engineering
• Award of the research price on 2007 `new generation Wissenschaftlerin´ in the context of the “monastery winter symposium”
• Excellent research work gets active substance search going crucially

Monastery, Switzerland, 16 January 2007. - Its research price 2007 for the promotion of the biotechnology and genetic engineering for a scientific break-through of the functional synthesis and integration of GPCR proteins in a Lipidmembran assigns Peter and Traudl angel horn donation. The new procedure makes possible to examine for the first time the natural functions of such a diaphragm protein in vitro.

For this Forschungsarbeit1) “Peter and Traudl angel horn donation distinguishes for the promotion of the biotechnology and genetic engineering” Dr. EH Kathrin Sinner (35), institute for Max-Planck for polymer research in Mainz, with their to research price 2007.

The research price is endowed and in conformity with the goals Peter and Traudl angel horn donation for outstanding research work by exzellenten new generation scientists is assigned with ten thousand euro.

Professor Dr. Herwig Brunner, executive committee speakers Peter and Traudl angel horn donation, explains: “This procedure permits the integration of a G-protein-coupled receptor diaphragm protein (GPCR) into a artifizielle, planar diaphragm from that to statue nascendi. Here takes place into vitro an arranged Insertion of the protein into the Lipiddoppelschicht.” Herwig Brunner continues to say: “To emphasize here, the employment of the diaphragm system used here is makes possible the analysis of further GPCRs and complex diaphragm proteins, those so far not for a detailed investigation was accessible.” “The 1971 born Preisträgerin EH Kathrin Sinner is an outstanding example of an excellent Wissenschaftlerin and stimulus of the growing up researcher colleague generation”, says Professor Brunner.

In-vitro-synthesis of G-proteins into a Lipidmembran

The characterisation of diaphragm proteins under preservation of its natural and biophysical function makes high demands against the biophysical measuring methods. While soluble proteins can determine usually easily and be manufactured in larger quantities, diaphragm proteins without their hydrophobe environment lose fast their native folding and thus their function.

The diaphragm protein is the “Türsteher” or “Gatekeeper” of the cell. It steers, which may penetrate proteins or materials into the cell or leave them. A further function is a “guard”: If a protein, for example an body-own anti-body, docks at the free ends of the diaphragm protein outside of the cell on, this releases a signal cascade. This is the trip of a broad spectrum of physiological processes in the cell. In particular the group of the G-protein-coupled receptors (GPCRs) rank among the main targets of the active substance research.

The most difficult task with the investigation of GPCRs is the isolation in its natural form, without changing their characteristics. In aqueous solution they would clump immediately. The recognition of the ligands impairs substantially.

EH Kathrin Sinner succeeded at the institute for Max-Planck for polymer research in Mainz to develop a strategy the structure and characterisation one of the most important representatives of the class of the GPCRs made possible. It showed this by the example of the smell receptor OR5 of the rat (Rattus norvegicus). Its isolation and investigation in functional Proteinkonformation had so far not been possible.
Sinner brought together using cDNA as raw material in vitro synthesized GPCR with an artificial Lipidmembran. The two-layered Lipidschicht was applied on a gold sensor. The synthetic Lipidmembran copied the characteristics of a natural Lipidmembran. An arranged Insertion of the smell receptor protein actually took place into the peptid fixed Lipidmembran. Thus difficult cleaning or isolation process can be avoided.

Award of the prize in monastery

On 16 January 2007 the official award of the prize of the research price Peter and Traudl angel horn donation takes place in the context of the renowned “monastery winter symposium” called by the Nobelpreisträger Professor Dr. Manfred own in the life in monastery, Switzerland.

Following the award of the prize the Nachwuchswissenschaftlerin with a paper on its work before a illustren scientific committee, in which several Nobelpreisträger will be represented, will represent.
Indication (mLZ): 4.296

Over the research price:
Peter and Traudl angel horn donation promote research project in the form new generation scientists particularly proven by scholarships for/inside. This preferably happens in the grant of two-year scholarships for Postdocs. Beyond that every two years a research price is written out.
Further information for applicants under www.engelhorn-stiftung.de.


Further information for the press under www.engelhorn-stiftung.de.
as well as:
1) Published under the title “incorporation of in vitro synthesized G-protein-coupled receptors into a peptidfixiertes artifizielles diaphragm system” into applied chemistry, 4 June 2006, Wiley VCH, DOI: 10.1002/ange.200602231, Abstract under www3.interscience.wiley.com/cgi-bin/abstract/113508983/ABSTRACT
2) www.roche.de/diagnostics/information.htm

Pictorial material: Inquiry at www.mpip-mainz.mpg.de/~sinner/ as well as with the donation.

Partner donation:
Professor Dr. Herwig Brunner
Donation executive committee Peter and Traudl angel horn donation
c/o institute for Fraunhofer for boundary surface and bio process engineering
Nobelstrasse 12
70569 Stuttgart
Tel.: 0711/970 4000
Fax.: 0711/970 4006
E-Mail: info. (RK) engelhorn stiftung.de
Web: www.engelhorn-stiftung.de
as well as www.ptes.de

Presseanfragen:
B´IMPRESS
Carolin Demler
Short change of gel 14
86156 Augsburg
Tel.: +49,821 5898-588
Fax: +49,821 5996-246
E-Mail: PSE (RK) bimpress.de
Web: www.bimpress.com

Over the donation:
The promotion of the scientific new generation set itself Peter and Traudl angel horn donation in the biotechnology and genetic engineering (life sciences) to the goal. It is a donation of Bavarian right.

It was created in memory of Peter Engelhorn. He was partner of the former Pharma enterprise Boehringer Mannheim. In the year 1998 Boehringer Mannheim von Roche was transferred, thereby to the world-wide number 1 in the Diagnostika business the aufstieg2).

Belong to the donation advice Peter and Traudl angel horn donation:
Professor Dr. Irenaeus Eibl Eibesfeld, presidency; Traudl Engelhorn Vechiatto; Ariane binder, Professor Dr. Robert Huber, Professor Dr. Dieter Oesterhelt, Pa Bernd Huber, RA Hans Christoph Beythan as well as the executive committees Professor Dr. Herwig Brunner, (speaker) and Hans Iser (finance executive committee).

The members of the donation price commission are:
Professor Dr. Manfred own, Goettingen; Dr. Ruthild Winkler Oswatitsch, Goettingen; Professor Dr. Dieter Oesterhelt, Munich; Professor Dr. Robert Huber, Munich; Patent lawyer Bernd Huber, Munich; Professor Dr. Eberhard Neumann, Bielefeld; Professor Dr. Walter Neupert, Munich; Professor Dr. Herwig Brunner, Stuttgart.

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